Orbit and optic nerve
Idiopathic sclerosing inflammation of orbit

Topic Completed: 1 February 2014

Minor changes: 3 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Idiopathic sclerosing inflammation [title] orbit

Nat Pernick, M.D.
Page views in 2019: 125
Page views in 2020 to date: 53
Cite this page: Pernick N. Orbit and optic nerve: idiopathic sclerosing inflammation of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitidiopathicsclerosing.html. Accessed June 1st, 2020.
Definition / general
  • Insidious, chronic and progressive fibrosing process
  • Damages orbital structures by entrapment and mass effect
  • May have cell mediated pathogenesis, similar to retroperitoneal fibrosis (Mod Pathol 1993;6:581)
Microscopic (histologic) description
  • Desmoplasia, sparse lymphocytes (usually T cells), histiocytes, plasma cells, neutrophils, eosinophils
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