Orbit and optic nerve
Idiopathic sclerosing inflammation of orbit

Author: Nat Pernick, M.D. (see Authors page)

Revised: 15 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Idiopathic sclerosing inflammation [title] orbit

Cite this page: Pernick, N. Orbit and optic nerve: idiopathic sclerosing inflammation of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitidiopathicsclerosing.html. Accessed November 17th, 2018.
Definition / general
  • Insidious, chronic and progressive fibrosing process
  • Damages orbital structures by entrapment and mass effect
  • May have cell mediated pathogenesis, similar to retroperitoneal fibrosis (Mod Pathol 1993;6:581)
Microscopic (histologic) description
  • Desmoplasia, sparse lymphocytes (usually T cells), histiocytes, plasma cells, neutrophils, eosinophils