Eye
Orbit and optic nerve
Metastases / spread to orbit

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Metastases [title] orbit

Cite this page: Pernick, N. Orbit and optic nerve: metastases / spread to orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitmetastases.html. Accessed September 20th, 2018.
Definition / general
  • Rarely is initial manifestation of childhood acute leukemia or adult carcinoma of breast, bronchus, kidney or prostate
  • Neuroblastoma and carcinoid tumor of lung or small bowel commonly metastasize to orbit (Hum Pathol 1982;13:459)
  • Primary embryonal rhabdomyosarcoma or carcinoid tumor of orbit may erroneously be interpreted as metastatic tumor
Clinical images

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Paranasal sinus carcinoma involving orbit

Gross images

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Paranasal sinus
carcinoma invades
nasal orbit

Microscopic (histologic) images

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Histiocytoid breast
carcinoma infiltrating
extraocular muscle



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Fig 8: metastatic neuroblastoma

Differential diagnosis