Eye
Orbit & optic nerve
Solitary fibrous tumor-orbit
Author: Nat Pernick, M.D.
Last author update: 1 February 2014
Last staff update: 6 March 2024
Copyright: 2004-2024, PathologyOutlines.com, Inc.
PubMed Search: solitary fibrous tumor orbit
Table of Contents
Definition / general | Prognosis and treatment | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Pernick N. Solitary fibrous tumor-orbit. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeorbitsft.html. Accessed April 20th, 2024.
Definition / general
- Usually benign but may be aggressive
- Lipomatous hemangiopericytoma may be variants of solitary fibrous tumor (Hum Pathol 2000;31:1108)
- References: Am J Surg Pathol 1994;18:281
Prognosis and treatment
- 30% recur, 15% metastasize (lung, liver, bone, regional lymph nodes), usually late
- Histology does not predict behavior (Hum Pathol 1982;13:210)
Case reports
- 58 year old man with t(9;22)(q31;p13) and orbital tumor (Arch Pathol Lab Med 2000;124:756)
- 66 year old woman with left eye proptosis, ptosis, and blindness (Arch Pathol Lab Med 2002;126:1555)
- Myxoid variant (Mod Pathol 1999;12:463)
Microscopic (histologic) description
- Usually encapsulated
- Random pattern of polygonal and rounded cells with ill defined cytoplasm, variable nucleoli
- Staghorn vascular pattern and perivascular collagen, dense pericellular reticulin, occasional mitotic figures
- Must rule out other tumors with this pattern
Microscopic (histologic) images
AFIP images
Small polyhedral cells surround vascular spaces
Vascular channels have a staghorn pattern
Cells are polyhedral and spindled, with mild atypia
Metastatic liver nodule
Positive stains
Negative stains
Differential diagnosis
- Fibrous histiocytoma:
- Predominant storiform pattern
- Foam cells and giant cells present
- Meningiomas:
- EMA positive
- Complex interdigitating processes and desmosomes by EM, deletions of #22
- Solitary fibrous tumor:
- CD34 strongly positive
