Orbit and optic nerve
Shaken baby syndrome and optic nerve

Topic Completed: 1 February 2014

Revised: 4 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: shaken baby syndrome optic

Nat Pernick, M.D.
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Page views in 2019 to date: 33
Cite this page: Pernick N. Orbit and optic nerve: shaken baby syndrome and optic nerve. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitshakenbabysyndrome.html. Accessed August 25th, 2019.
Definition / general
  • Defined as intentional whiplash movement of infant's head
  • Can be detected by beta-amyloid precursor protein immunohistochemistry to identify optic nerve damage in optic disk or distal optic nerve
  • Takes at least 2 hours to develop, staining intensity should exceed background
  • Also have severe bilateral, often multilayered retinal hemorrhages
Microscopic (histologic) images

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Fig 1A: intense beta amyloid precursor protein staining in distal optic nerve caudal to lamina cribrosa; B: high power shows axonal beading and small swellings; C: H&E does not show axonal swellings; D: neurofilament stain doesn't detect axonal injury
Fig 2: beta amyloid precursor protein of retina shows extensive focal axonal injury within nerve fiber layer
Fig 3: distal optic nerve of SIDS infant shows weak beta amyloid precursor protein staining without beading or swelling

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