Eye
Orbit and optic nerve
TNM staging for ocular adnexal lymphoma


Topic Completed: 1 February 2014

Revised: 4 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: TNM staging for ocular adnexal lymphoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Orbit and optic nerve: TNM staging for ocular adnexal lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbittnmlymphoma.html. Accessed October 16th, 2019.

Pathologic TNM staging of ocular adnexal lymphoma, AJCC 7th edition
Primary tumor (T)
  • TX: lymphoma extent not specified
  • T0: no evidence of lymphoma
  • T1: lymphoma involving the conjunctiva alone without orbital involvement
  • T1a: bulbar conjunctiva alone
  • T1b: palpebral conjunctiva, +/- fornix, +/- caruncle
  • T1c: extensive conjunctival involvement
  • T2: lymphoma with orbital involvement +/- any conjunctival involvement
  • T2a: anterior orbital involvement (+/- any conjunctival involvement)
  • T2b: anterior orbital involvement (+/- any conjunctival involvement but with lacrimal involvement)
  • T2c: posterior orbital involvement (+/- any conjunctival involvement, +/- anterior involvement, +/- any extraocular muscle involvement)
  • T2d: nasolacrimal drainage system involvement (+/- conjunctival involvement but not including nasopharynx)
  • T3: lymphoma with preseptal eyelid involvement (infiltrates preseptal tissues such as dermis or orbicularis muscle of anterior eyelid skin) +/- orbital involvement, +/- any conjunctival involvement
  • T4: orbital adnexal lymphoma extending beyond orbit to adjacent structures such as bone and brain
  • T4a: involvement of nasopharynx
  • T4b: osseous involvement (including periosteum)
  • T4c: involvement of maxillofacial, ethmoidal or frontal sinuses
  • T4d: intracranial spread
Regional lymph nodes (N)
  • NX: involvement of lymph nodes not assessed
  • N0: no evidence of lymph node involvement
  • N1: involvement of ipsilateral regional lymph nodes
  • N2: involvement of contralateral or bilateral regional lymph nodes
  • N3: involvement of peripheral lymph nodes not draining ocular adnexal region
  • N4: involvement of central lymph nodes

  • Notes: regional lymph nodes include preauricular (parotid), submandibular and cervical
Distant metastasis (M)
  • M0: no evidence of involvement of other extranodal sites
  • M1a: noncontiguous involvement of tissues or organs external to the ocular adnexa (e.g. parotid glands, submandibular gland, lung, liver, spleen, kidney, breast, etc.)
  • M1b: lymphomatous involvement of the bone marrow
  • M1c: both M1a and M1b involvement
Stage grouping
  • No stage grouping is presently recommended by AJCC 7th edition
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