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Eye
Conjunctiva
Primary acquired melanosis

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 13 April 2013, last major update April 2013
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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Conjunctival melanocytic intra-epithelial neoplasia (C-MIN)
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C-MIN scoring system
Clinical features
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Prognostic factors
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Case reports
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Treatment
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Clinical images
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Diffuse involvement
Flat diffuse pigmentation of the fornix and palpebral conjunctiva
Gross description
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Micro description
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Micro images
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Without atypia:
Melanocytic hyperplasia is confined to basilar layer

With atypia:
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Fig 1: Minimal atypia due to mildly atypical melanocytes in basilar layer
Fig 2: Moderate atypia due to nests of atypical melanocytes extending throughout epithelial thickness
Fig 3: Severe atypia with nests and individual epithelioid melanocytes extending throughout epithelial thickness in pagetoid fashion
Fig 4: Severe atypia due to spindled malignant melanocytes that completely replace the conjunctival epithelium, with minimal invasion of the inflamed substantial propria
Fig 5: Cellular atypia, nesting and discohesion

Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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End of Eye > Conjunctiva > Primary acquired melanosis


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