Pseudoepitheliomatous hyperplasia

Topic Completed: 1 October 2014

Revised: 26 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Pseudoepitheliomatous hyperplasia conjunctiva

Deepali Jain, M.D.
Page views in 2018: 428
Page views in 2019 to date: 573
Cite this page: Jain D. Conjunctiva: pseudoepitheliomatous hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyepseudoepitheliomatoushyperplasiaconjun.html. Accessed October 15th, 2019.
Definition / general
  • Response to chronic conjunctival irritation or inflammation
  • Develops rapidly, may ulcerate
Case reports
  • Remove cause of inflammation
Gross description
  • Pink mass with leukoplakia
Microscopic (histologic) description
  • Reactive epithelial proliferation with irregular lobules containing variable acanthosis and keratinization, parakeratosis
  • Reactive epithelial changes, inflammation and mitotic activity
  • May have ill defined border with subepithelial connective tissue due to inflammation
  • No nuclear atypia
Microscopic (histologic) images

AFIP images
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Resembles squamous cell carcinoma

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Infiltrating squamous cells are benign

Differential diagnosis
  • Fungi: multinucleated giant cells
  • Pseudoadenomatous hyperplasia: reactive gland-like proliferation resembling mucoepidermoid carcinoma
  • Squamous cell carcinoma: atypical cells, individual cell keratinization
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