Pseudoepitheliomatous hyperplasia

Author: Deepali Jain, M.D. (see Authors page)

Revised: 23 April 2018, last major update October 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Pseudoepitheliomatous hyperplasia conjunctiva

Cite this page: Jain, D. Conjunctiva: pseudoepitheliomatous hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyepseudoepitheliomatoushyperplasiaconjun.html. Accessed April 25th, 2018.
Definition / general
  • Response to chronic conjunctival irritation or inflammation
  • Develops rapidly, may ulcerate
Case reports
  • Remove cause of inflammation
Gross description
  • Pink mass with leukoplakia
Microscopic (histologic) description
  • Reactive epithelial proliferation with irregular lobules containing variable acanthosis and keratinization, parakeratosis
  • Reactive epithelial changes, inflammation and mitotic activity
  • May have ill defined border with subepithelial connective tissue due to inflammation
  • No nuclear atypia
Microscopic (histologic) images

Images hosted on PathOut server:
Missing Image

Resembles squamous cell carcinoma

Missing Image

Infiltrating squamous cells are benign

Differential diagnosis
  • Fungi: multinucleated giant cells
  • Pseudoadenomatous hyperplasia: reactive gland-like proliferation resembling mucoepidermoid carcinoma
  • Squamous cell carcinoma: atypical cells, individual cell keratinization