Retrolental fibroplasia of retina

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Retrolental fibroplasia [title] retina

Cite this page: Pernick, N. Retina: retrolental fibroplasia of retina. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeretinaretrolentalfibroplasia.html. Accessed September 21st, 2018.
Definition / general
  • Also called retinopathy of prematurity
  • Previously was leading cause of blindness in US
  • Occurs in premature infants given oxygen therapy; related to level and duration of oxygen, degree of prematurity at birth and status as carrier for defect in Norrie disease gene
  • Immature vessels of premature infants are damaged by high or even physiologic oxygen; rarely occurs in term infants
  • Oxygen therapy causes vasoconstriction and obliteration of immature retinal vessels in lateral (temporal) retina which causes ischemia and failure of retina to vascularize
  • Then vasoproliferative phase and angiogenesis
  • Vessels grow into vitreous or leak serum or fluid, 25% have associated scarring which causes retinal detachment