Eye
Retina
TNM staging for retinoblastoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 April 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: TNM staging for retinoblastoma [title]

Cite this page: Pernick, N. TNM staging for retinoblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeretinatnmretinoblastoma.html. Accessed October 18th, 2018.

Pathologic TNM staging of retinoblastoma, AJCC 7th edition
Primary tumor (T)
  • pTX: primary tumor cannot be assessed
  • pT0: no evidence of primary tumor
  • pT1: tumor confined to eye with no optic nerve or choroidal invasion
  • pT2: tumor with minimal optic nerve or choroidal invasion
  • pT2a: tumor superficially invades optic nerve head but does not extend past lamina cribrosa OR tumor exhibits focal choroidal invasion, but not both
  • pT2b: tumor superficially invades optic nerve head but does not extend past lamina cribrosa AND exhibits focal choroidal invasion
  • pT3: tumor with significant optic nerve or choroidal invasion
  • pT3a: tumor invades optic nerve past lamina cribrosa but not to surgical resection line OR tumor exhibits massive choroidal invasion, but not both
  • pT3b: tumor invades optic nerve past lamina cribrosa but not to surgical resection line AND exhibits massive choroidal invasion
  • pT4: tumor invades optic nerve to resection line OR exhibits extraocular extension elsewhere, but not both
  • pT4a: tumor invades optic nerve to resection line but no extraocular extension identified
  • pT4b: tumor invades optic nerve to resection line AND extraocular extension identified
Regional lymph nodes (N)
  • pNX: regional lymph nodes cannot be assessed
  • pN0: no regional lymph node involvement
  • pN1: regional lymph node involvement (preauricular, cervical)
  • N2: distant lymph node involvement
Metastasis (M)
  • cM0: no metastasis
  • pM1: metastasis to sites other than CNS
  • pM1a: single lesion
  • pM1b: multiple lesions
  • pM1c: CNS metastasis
  • pM1d: discrete mass(es) without leptomeningeal or CSF involvement
  • pM1e: leptomeningeal or CSF involvement
Stage grouping
  • No stage grouping is presently recommended by AJCC 7th edition