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General
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Prognostic factors
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Treatment
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Clinical images
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Ciliary body tumor with extraocular extension mimics a primary conjunctival tumor

Fundoscopic images
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Small tumor with orange pigment on surface

Vessels over tumor dome are out of focus due to elevation of tumor

Gross images
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Small, heavily pigmented choroidal tumor

Heavily pigmented, mushroom shaped choroidal tumor

Large transillumination defect due to pigmented tumor of ciliary body and choroid

Small pigmented tumor confined to choroid

Variably pigmented, mushroom
shaped choroidal tumor has
ruptured Bruch's membrane and
grown into subretinal space


Mushroom shaped choroidal tumor has caused a subretinal hemorrhage and total retinal detachment; #2: hemorrhage is partially organized

Amelanotic mushroom shaped
choroidal tumor has caused
a total retinal detachment

Diffusely pigmented choroidal
tumor with massive
extraocular extension


Heavily pigmented
ciliary body tumor
excised by
iridocyclectomy

Lightly pigmented tumor of ciliary body

Large iris and
ciliary body tumor
with subluxation
of lens

Amelanotic large choroidal tumor with extraocular extension

Vortex vein invasion

Whole mount images
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Tumor is composed of tightly packed melanoma cells

Tumor extends from
ciliary body to optic nerve,
and has caused an exudative
retinal detachment

Diffuse tumor involving entire
uveal tract, with extra-
ocular extension anteriorly
in a ring configuration

Large choroidal tumor with extraocular extension

Micro description
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Micro images
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Melanocytes

Spindle cell melanoma

Nodular area of spindle cells with extraocular extension

Mushroom shaped choroidal tumor with exudative retinal detachment

Focal necrosis and scleral invasion


Ciliary body tumor with necrosis and hemorrhage

Seeding of anterior chamber angle by small epithelioid cells

Partially necrotic tumor

Tumor infiltrating lymphocytes

Spindle A cells


Spindle B cells #1 in bundles; #2: with prominent nucleoli

Spindled and epithelioid cells

Small epithelioid cells

Large epithelioid cells with large nucleoli and lack of cohesion

Vasocentric pattern with tumor cells palisading around blood vessels


Verocay-like pattern

HMB45+



Iris:

Large iris tumor has extended to ciliary body

Recurrent diffuse tumor of iris post-iridectomy

Iris involvement by small epithelioid cells

Iridectomy specimen containing a spindle cell tumor; #2: nevus cells, spindle shaped melanoma cells and large thrombosed vessel; #3: spindle A and B cells


Positive stains
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Molecular description
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Differential diagnosis
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End of Eye > Uvea > Melanoma of uvea



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