Sarcoidosis in uvea

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Sarcoidosis [title] uvea

Cite this page: Pernick, N. Uvea: sarcoidosis in uvea. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeuveasarcoidosis.html. Accessed November 17th, 2018.
Definition / general
  • Systemic granulomatous disease, usually affecting young adult blacks
  • Uvea involved in 1/3
  • May cause "mutton-fat" corneal precipitates; also granulomas in choroid, retinal perivascular inflammation with candle wax drippings near retinal vessels and retinal hemorrhages
  • Patients often have conjunctival granulomas (noncaseating)
Microscopic (histologic) description
  • Noncaseating granulomas
  • Also asteroid bodies (small, eosinophilic star shaped inclusions in epithelioid cells) or Schaumann bodies (darker ovoid inclusions)
Differential diagnosis