Sympathetic uveitis

Topic Completed: 1 February 2014

Minor changes: 8 April 2019

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PubMed Search: Sympathetic uveitis [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Uvea: sympathetic uveitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeuveasympatheticuveitis.html. Accessed May 29th, 2020.
Definition / general
  • Also called sympathetic ophthalmia
  • Rare; injury in one eye causes severe inflammation that may progress to blindness in uninjured as well as injured eye via presumed autoimmune response to retinal antigens
  • Lesion usually confined to uveal tissues and involving entire uveal tract
  • Retina may develop perivasculitis; injured lens develops phakogenic endophthalmitis
  • Immunosuppressive agents
Microscopic (histologic) description
  • Diffuse and dense infiltration of choroid by lymphocytes and granulomas
  • Also similar involvement of ciliary body and iris
  • Patchy accumulations of small, irregular pale staining epithelioid cells (Dalen-Fuchs nodules) containing fine melanin granules
  • Moderate eosinophils, rare plasma cells and no neutrophils
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