Eye
Uvea
Sympathetic uveitis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Sympathetic uveitis [title]

Cite this page: Pernick, N. Uvea: sympathetic uveitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeuveasympatheticuveitis.html. Accessed September 20th, 2018.
Definition / general
  • Also called sympathetic ophthalmia
  • Rare; injury in one eye causes severe inflammation that may progress to blindness in uninjured as well as injured eye via presumed autoimmune response to retinal antigens
  • Lesion usually confined to uveal tissues and involving entire uveal tract
  • Retina may develop perivasculitis; injured lens develops phakogenic endophthalmitis
Treatment
  • Immunosuppressive agents
Microscopic (histologic) description
  • Diffuse and dense infiltration of choroid by lymphocytes and granulomas
  • Also similar involvement of ciliary body and iris
  • Patchy accumulations of small, irregular pale staining epithelioid cells (Dalen-Fuchs nodules) containing fine melanin granules
  • Moderate eosinophils, rare plasma cells and no neutrophils