Fallopian tubes
Benign or nonneoplastic conditions
Amyloidosis

Author: Nicole Riddle, M.D. (see Authors page)

Revised: 28 July 2017, last major update March 2013

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PubMed Search: Fallopian tubes Benign or non-neoplastic conditions Amyloidosis

Cite this page: Amyloidosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/fallopiantubesamyloidosis.html. Accessed August 16th, 2017.
Definition / general
  • Very rare; infiltration of fallopian tube by amyloid protein, usually associated with generalized abdominal amyloid involvement
Epidemiology
  • Renal dialysis patients, elderly, plasma cell dyscrasias
Pathophysiology
  • Arises as proteins become insoluble, are deposited in extracellular space of various tissues / organs or disrupt normal function
  • Change in the protein's secondary structure causes the protein to aggregate in insoluble form and form beta-pleated sheet
Diagnosis
  • Amorphous eosinophilic proteins on H&E, confirmed by Congo red with apple green birefringence on polarization
  • Thioflavin T stain may be helpful
Case reports
  • 56 year old woman on renal dialysis with beta 2 microglobulin amyloidosis presenting as bilateral ovarian masses with involvement of fallopian tubes (Am J Surg Pathol 2002;26:130)
Gross description
  • May be unremarkable or show a mass lesion
Microscopic (histologic) description
  • Extracellular amorphous eosinophilic material
Microscopic (histologic) images

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Amyloid with Congo red staining and apple green birefringence in cardiac muscle