Benign or non-neoplastic conditions
Reviewer: Nicole Riddle, M.D. (see Reviewers page)
Editor: Jamie Shutter, M.D.
Revised: 19 March 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Very rare; infiltration of fallopian tube by amyloid protein, usually associated with generalized abdominal amyloid involvement
- Renal dialysis patients, elderly, plasma cell dyscrasias
- Arises as proteins become insoluble, are deposited in extracellular space of various tissues / organs, or disrupt normal function
- Change in the protein's secondary structure causes the protein to aggregate in insoluble form and form beta-pleated sheet
- Amorphous eosinophilic proteins on H&E, confirmed by Congo Red with apple-green birefriengence on polarization
- Thioflavin T stain may be helpful
- 56 year old woman on renal dialysis with beta 2 microglobulin amyloidosis presenting as bilateral ovarian masses with involvement of fallopian tubes
(Am J Surg Pathol 2002;26:130)
- May be unremarkable or show a mass lesion
- Extracellular amorphous eosinophilic material
End of Fallopian tubes > Benign or non-neoplastic conditions > Amyloidosis
Amyloid with Congo red staining and apple green birefringence in cardiac muscle
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected]
with any questions (click here for other