Benign or non-neoplastic conditions
Reviewer: Nicole Riddle, M.D. (see Reviewers page)
Editor: Jamie Shutter, M.D.
Revised: 19 March 2013, last major update March 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Very rare; infiltration of fallopian tube by amyloid protein, usually associated with generalized abdominal amyloid involvement
- Renal dialysis patients, elderly, plasma cell dyscrasias
- Arises as proteins become insoluble, are deposited in extracellular space of various tissues / organs, or disrupt normal function
- Change in the protein's secondary structure causes the protein to aggregate in insoluble form and form beta-pleated sheet
- Amorphous eosinophilic proteins on H&E, confirmed by Congo Red with apple-green birefriengence on polarization
- Thioflavin T stain may be helpful
- 56 year old woman on renal dialysis with beta 2 microglobulin amyloidosis presenting as bilateral ovarian masses with involvement of fallopian tubes
(Am J Surg Pathol 2002;26:130)
- May be unremarkable or show a mass lesion
- Extracellular amorphous eosinophilic material
End of Fallopian tubes > Benign or non-neoplastic conditions > Amyloidosis
Amyloid with Congo red staining and apple green birefringence in cardiac muscle
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