Fallopian tubes
Benign / nonneoplastic
Arias-Stella reaction

Topic Completed: 1 March 2013

Revised: 23 August 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Arias-Stella reaction

Nicole Riddle, M.D.
Jamie Shutter, M.D.
Page views in 2018: 421
Page views in 2019 to date: 410
Cite this page: Riddle N, Shutter J. Arias-Stella reaction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/fallopiantubesarias.html. Accessed November 19th, 2019.
Definition / general
  • Benign change of epithelium typically seen during pregnancy or during hormone therapy
  • First described in 1954 by Javier Arias Stella, a Peruvian pathologist
Clinical features
  • Present in fallopian tube in ~16% of ectopic tubal pregnancies
  • Rarely associated with intrauterine pregnancy
Case reports
Microscopic (histologic) description
  • Large epithelioid cells with atypical nuclei; rarely clear cytoplasm
  • May also have irregular nuclear membrane, granular chromatin, centronuclear vacuolization, pseudonuclear inclusions
  • Subtypes:
    • Early secretory pattern
    • Secretory or hypersecretory pattern
    • Regenerative
    • Proliferative or nonsecretory pattern
    • Monstrous cell pattern
Microscopic (histologic) images

AFIP images

Epithelial cell nuclei enlarged and smudgy


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