Fallopian tubes
Benign or nonneoplastic conditions
Arias-Stella reaction

Author: Nicole Riddle, M.D. (see Authors page)
Editor: Jamie Shutter, M.D.

Revised: 28 July 2017, last major update March 2013

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PubMed Search: Arias-Stella reaction

Cite this page: Arias-Stella reaction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/fallopiantubesarias.html. Accessed October 15th, 2018.
Definition / general
  • Benign change of epithelium typically seen during pregnancy or during hormone therapy
  • First described in 1954 by Javier Arias Stella, a Peruvian pathologist
Clinical features
  • Present in fallopian tube in ~16% of ectopic tubal pregnancies
  • Rarely associated with intrauterine pregnancy
Case reports
Microscopic (histologic) description
  • Large epithelioid cells with atypical nuclei; rarely clear cytoplasm
  • May also have irregular nuclear membrane, granular chromatin, centronuclear vacuolization, pseudonuclear inclusions
  • Subtypes:
    • Early secretory pattern
    • Secretory or hypersecretory pattern
    • Regenerative
    • Proliferative or nonsecretory pattern
    • Monstrous cell pattern
Microscopic (histologic) images

Images hosted on PathOut server

Epithelial cell nuclei enlarged and smudgy