Fallopian tubes
Benign / nonneoplastic

Topic Completed: 1 April 2013

Minor changes: 13 December 2019

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PubMed Search: Fallopian tubes and Endosalpingiosis

Nicole Riddle, M.D.
Jamie Shutter, M.D.
Page views in 2019: 2,529
Page views in 2020 to date: 1,222
Cite this page: Riddle N, Shutter J. Endosalpingiosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/fallopiantubesendosalpingiosis.html. Accessed May 31st, 2020.
Definition / general
  • Benign condition in which fallopian tube-like epithelium is found outside the fallopian tube
  • Women of all ages, even postmenopausal (40% of cases)
  • ~35% of cases have concurrent endometriosis
  • Gynecologic malignancy occurs significantly more in premenopausal women with endosalpingiosis than in those without (Fertil Steril 2012;98:942)
Clinical features
Case reports
Gross description
  • No specific gross findings, may present as fibrous nodule in omentum or rarely as mass
Microscopic (histologic) description
  • Variably dilated glands with tubal type (i.e. ciliated) epithelium surrounded by fibrous stroma
  • May have psammoma bodies (J Reprod Med 1991;36:675)
  • Unlike endometriosis, not associated with hemorrhage
  • Note: a tubal type epithelium surrounded by endometrial type stroma is a variant of endometriosis, not endosalpingiosis
Microscopic (histologic) images

AFIP images

Fallopian tube epithelium in fibrous stroma

Images hosted on other servers

Lymph node with endosalpingiosis

Positive stains
Negative stains
  • TTF1, mammaglobin, p53 (when benign), low Ki-67 (MIB1) (when benign)
  • CD34, calretinin, SMA may distinguish endosalpingiosis and tumor: endosalpingiotic stroma is CD34+, calretinin-, SMA-; stroma surrounding invasive implants is CD34-, calretinin-, SMA+; noninvasive implants are CD34+ [68%], calretinin+ [72%], SMA + / - [50%]) (Mod Pathol 2006;19:364)
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