Fallopian tubes
Benign or nonneoplastic conditions

Author: Nicole Riddle, M.D. (see Authors page)
Editor: Jamie Shutter, M.D.

Revised: 6 July 2018, last major update April 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Fallopian tubes and Endosalpingiosis

Cite this page: Riddle, N. Endosalpingiosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/fallopiantubesendosalpingiosis.html. Accessed October 15th, 2018.
Definition / general
  • Benign condition in which fallopian tube-like epithelium is found outside the fallopian tube
  • Women of all ages, even postmenopausal (40% of cases)
  • ~35% of cases have concurrent endometriosis
  • Gynecologic malignancy occurs significantly more in premenopausal women with endosalpingiosis than in those without (Fertil Steril 2012;98:942)
Clinical features
Case reports
Gross description
  • No specific gross findings, may present as fibrous nodule in omentum or rarely as mass
Microscopic (histologic) description
  • Variably dilated glands with tubal type (i.e. ciliated) epithelium surrounded by fibrous stroma
  • May have psammoma bodies (J Reprod Med 1991;36:675)
  • Unlike endometriosis, not associated with hemorrhage
  • Note: a tubal type epithelium surrounded by endometrial type stroma is a variant of endometriosis, not endosalpingiosis
Microscopic (histologic) images

Images hosted on PathOut server

Fallopian tube epithelium in fibrous stroma

Images hosted on other servers

Lymph node with endosalpingiosis

Positive stains
Negative stains
  • TTF1, mammaglobin, p53 (when benign), low Ki-67 (MIB1) (when benign)
  • CD34, calretinin, SMA may distinguish endosalpingiosis and tumor: endosalpingiotic stroma is CD34+, calretinin-, SMA-; stroma surrounding invasive implants is CD34-, calretinin-, SMA+; noninvasive implants are CD34+ [68%], calretinin+ [72%], SMA + / - [50%]) (Mod Pathol 2006;19:364)