Fallopian tubes & broad ligament
Fallopian tube tumor-like lesions
Tubo-ovarian abscess
Authors: Nicole D. Riddle, M.D., Jamie Shutter, M.D.
Last author update: 1 March 2011
Last staff update: 22 April 2024 (update in progress)
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Fallopian tubes [title] salpingitis
Table of Contents
Definition / general | Terminology | Epidemiology | Etiology | Clinical features | Case reports | Treatment | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosis | Additional referencesCite this page: Riddle N, Shutter J. Tubo-ovarian abscess. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/fallopiantubessalpingitis.html. Accessed April 28th, 2024.
Definition / general
- Inflammation of fallopian tube, most commonly sexually transmitted due to chlamydia and gonorrhea
Terminology
- Part of spectrum of pelvic inflammatory disease (PID)
Epidemiology
- > 1 million cases of acute salpingitis reported annually in US but actual number probably larger due to incomplete and untimely reporting
- For women 16 - 25 years, salpingitis is most common serious infection; affects 11% of females of reproductive age, 12% of women before age 20
- Salpingitis has higher incidence among lower socioeconomic classes, possibly due to earlier sex debut, multiple partners, poorer health care
- Highest risk for people aged 15 - 24 years, possibly due to multiple partners, less awareness of symptoms, reduced willingness to use protective contraceptives
- Infection also occurs via childbirth, abortion (therapeutic or elective), endometrial biopsy, IUD insertion, miscarriage
- In 2005, World Health Organization (WHO) estimated 448 million new cases of curable STIs occur annually in individuals aged 15 - 49 years
Etiology
- Bacteria most associated with salpingitis are: actinomyces, Chlamydia trachomatis, enteric gram - negative rods (eg. E. coli), Gardnerella vaginalis, Haemophilus influenza, Mycoplasma, Neisseria gonorrhoeae, rarely other anaerobic and aerobic bacteria, Staphylococcus, Streptococcus, Trichomonos vaginalis, Ureaplasma urealyticum
- Also Herpes and CMV, fungi, parasites
- 30 - 40% are polymicrobial
- In US, chlamydia is #1 most reported sexually transmitted disease associated with PID, N. gonorrhoeae is #2
- 10 - 20% of untreated chlamydial or gonorrheal infections progress to PID
Clinical features
- Symptoms usually appear after a menstrual period; most commonly abdominal pain, abnormal smell and color of vaginal discharge, bloating, fever, lower back pain, nausea, pain during ovulation, pain during periods, pain during sexual intercourse, vomiting
- Tubo-ovarian abscess in 1/3 of women hospitalized for PID
- Often asymptomatic, may be diagnosed clinically by pelvic examination, blood tests, vaginal or cervical swab
- PID has 3 principal complications: chronic pelvic pain (~25%), infertility, ectopic pregnancy (15 - 50%)
- Impaired fertility is major concern; infection and inflammation can lead to scarring and adhesions within tubal lumens
- Of women with tubal factor infertility, 50% have no history of PID but have scarring of fallopian tubes and exhibit antibodies to C. trachomatis
- May lead to tubule ovarian abscess, pelvic peritonitis, Fitz-Hugh-Curtis syndrome (perihepatitis)
- Taiwanese studies of > 60,000 women diagnosed with PID found that PID was independent risk factor for myocardial infarction in women > age 55 (Int J Cardiol 2013;167:416), with increased risk of stroke for 3 years following PID (Stroke 2011;42:2074); also increased risk of ovarian cancer, particularly in women with 5+ episodes of PID (Lancet Oncol 2011;12:900)
Case reports
- 46 year old woman with S. pneumonia (Hum Pathol 1990;21:1288)
- 50 year old woman with focally calcified cysticercus larva (Hum Pathol 1982;13:665)
Treatment
- Antibiotics or antifungals
Gross description
- Pyosalpinx (pus), hematosalpinx
- Enlarged, erythematous, edematous
- May have fibrinous exudate
- Tubo-ovarian abscess common
Gross images
Images hosted on other servers:
Tubo-ovarian abscess from Neisseria gonorrheae
Microscopic (histologic) description
- Marked neutrophilic infiltrate, congestion and edema
- Mucosal ulceration
- Reactive epithelial changes
- Variable abscess formation, variable presence of microorganisms
Microscopic (histologic) images
Images hosted on other servers:
Neisseria gonorrheae
H&E
Differential diagnosis
- Ectopic pregnancy
- Hydrosalpinx: transudate, follows purulent salpingitis
- Menstruation / pregnancy: neutrophils common but usually don't invade muscularis, no necrosis, no ulceration, no chronic inflammatory infiltrate
