Walthard cell nests
Reviewer: Nicole Riddle, M.D. (see Reviewers page)
Editor: Jamie Shutter, M.D.
Revised: 10 April 2014, last major update September 2013
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PubMed Search: Walthard cell nests [title]
- Benign epithelial cell clusters found in peri-fallopian tube tissue
- Also called transitional / urethelial cell metaplasia
- May be found anywhere in broad ligament, including ovarian hilum
- May be source of Brenner tumors or primary urethelial cell carcinomas (parafallopian tube transitional cell carcinoma) (Gynecol Oncol 2002;86:379)
- May be white/yellow nodules or cysts up to 2 mm
- Often an incidental microscopic finding
Several small yellow nodules clustered on serosa of isthmic portion of tube
- Well circumscribed, small, round collections of flat to cuboidal cells with minimal atypia
- Elliptical nuclei with prominent nuclear grooves, 1-2 small nucleoli
- May see inspissated eosinophilic secretion or mucin within lumina
- No / rare mitotic figures
Warthard cell nests at lower right
Note "coffee bean" nuclei
- CK20, uroplakin (Brenner tumors are uroplakin+)
End of Fallopian tubes > Benign/non-neoplastic > Walthard cell nests
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