Fallopian tubes
Benign or nonneoplastic conditions
Walthard cell nests

Author: Nicole Riddle, M.D. (see Authors page)
Editor: Jamie Shutter, M.D.

Revised: 11 August 2017, last major update September 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Walthard cell nests

Cite this page: Walthard cell nests. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/fallopiantubeswalthard.html. Accessed October 22nd, 2018.
Definition / general
  • Benign epithelial cell clusters found in perifallopian tube tissue
  • Also called transitional / urethelial cell metaplasia
  • May be found anywhere in broad ligament, including ovarian hilum
  • May be source of Brenner tumors or primary urethelial cell carcinomas (parafallopian tube transitional cell carcinoma, Gynecol Oncol 2002;86:379)
Gross description
  • May be white / yellow nodules or cysts up to 2 mm
  • Often an incidental microscopic finding
Gross images

Images posted on PathOut server:

Several small yellow
nodules clustered on
serosa of isthmic
portion of tube

Microscopic (histologic) description
  • Well circumscribed, small, round collections of flat to cuboidal cells with minimal atypia
  • Elliptical nuclei with prominent nuclear grooves, 1 - 2 small nucleoli
  • May see inspissated eosinophilic secretion or mucin within lumina
  • No / rare mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Various images

Images hosted on other servers:

Warthard cell nests at lower right

Note "coffee bean" nuclei

Positive stains
  • CK7, involucrin
Negative stains
Differential diagnosis