Malignant gallbladder tumors
Carcinoma in situ

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 6 February 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Carcinoma in situ[TIAB] gallbladder

Cite this page: Gulwani, H. Carcinoma in situ. website. Accessed July 21st, 2018.
Definition / general
Diagrams / tables

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Comparison of CIS with invasive carcinoma

Microscopic (histologic) description
  • May extend into Rokitansky-Aschoff sinuses resembling invasive carcinoma but is connected to surface epithelium (Am J Surg Pathol 2004;28:621)
  • Mixture of benign and neoplastic epithelium
  • Has inspissated bile in long dilated spaces
  • Desmoplasia but no invasion into smooth muscle bundles, no perineurial invasion
  • May arise in adenomyomatous hyperplasia
Microscopic (histologic) images

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Various images