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Malignant gallbladder tumors

Intracholecystic papillary tubular neoplasm

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Preinavsive neoplasms at least 1 cm (Am J Surg Pathol 2012;36:1279)
● Analogous to pancreatic (IPMN) and biliary counterparts
● Show variable cellular lineages with a spectrum of dysplasia, mixture of papillary or tubular growth patterns
● Relatively indolent behavior - better prognosis than pancreatobiliary-type gallbladder carcinoma

Gross images

Hilar tumor whose connective tissue contains multiple cysts, some associated with intracystic papillary or solid nodules (arrows)

Micro images

A: cysts are either lined by flat epithelium or occupied by tumor; B: cyst contains intracystic papillary nodule; C/D: tumor shows papillary and tubular proliferation; E: tumor contains moderately pleomorphic adenocarcinoma cells with focal neutrophils; F: portion of cyst lined by non-neoplastic cuboidal epithelium (upper) which contrasts with carcinoma (lower)

Immunostains: CK7+, MUC1+, MUC6+, MUC5AC-

End of Gallbladder > Malignant gallbladder tumors > Intracholecystic papillary tubular neoplasm

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