Extrahepatic bile ducts
Intracholecystic papillary tubular neoplasm

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 8 February 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Intracholecystic papillary tubular neoplasm

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Cite this page: Gulwani, H. Intracholecystic papillary tubular neoplasm. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderICPN.html. Accessed January 21st, 2019.
Definition / general
  • Preinavsive neoplasms at least 1 cm (Am J Surg Pathol 2012;36:1279)
  • Analogous to pancreatic (IPMN) and biliary counterparts
  • Show variable cellular lineages with a spectrum of dysplasia, mixture of papillary or tubular growth patterns
  • Relatively indolent behavior - better prognosis than pancreatobiliary type gallbladder carcinoma
Gross images

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Hilar tumor whose connective tissue contains multiple cysts, some associated with intracystic papillary or solid nodules (arrows)

Microscopic (histologic) images

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A: cysts are either lined by flat epithelium or occupied by tumor;
B: cyst contains intracystic papillary nodule; C / D: tumor shows papillary and tubular proliferation;
E: tumor contains moderately pleomorphic adenocarcinoma cells with focal neutrophils;
F: portion of cyst lined by nonneoplastic cuboidal epithelium (upper) which contrasts with carcinoma (lower)

Immunostains: CK7+, MUC1+, MUC6+, MUC5AC-