Extrahepatic bile ducts
Tumors
Intracholecystic papillary tubular neoplasm


Topic Completed: 1 September 2012

Revised: 22 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Intracholecystic papillary tubular neoplasm
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Cite this page: Gulwani H Intracholecystic papillary tubular neoplasm. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderICPN.html. Accessed May 24th, 2019.
Definition / general
  • Preinavsive neoplasms at least 1 cm (Am J Surg Pathol 2012;36:1279)
  • Analogous to pancreatic (IPMN) and biliary counterparts
  • Show variable cellular lineages with a spectrum of dysplasia, mixture of papillary or tubular growth patterns
  • Relatively indolent behavior - better prognosis than pancreatobiliary type gallbladder carcinoma
Gross images

Images hosted on other servers:

Hilar tumor whose connective tissue contains multiple cysts, some associated with intracystic papillary or solid nodules (arrows)

Microscopic (histologic) images

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A: cysts are either lined by flat epithelium or occupied by tumor;
B: cyst contains intracystic papillary nodule; C / D: tumor shows papillary and tubular proliferation;
E: tumor contains moderately pleomorphic adenocarcinoma cells with focal neutrophils;
F: portion of cyst lined by nonneoplastic cuboidal epithelium (upper) which contrasts with carcinoma (lower)


Immunostains: CK7+, MUC1+, MUC6+, MUC5AC-

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