Gallbladder
Benign gallbladder tumors
Adenoma of gallbladder

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 6 February 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Adenoma[TI] gallbladder[TI]

Cite this page: Gulwani, H. Adenoma of gallbladder. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderadenomaGB.html. Accessed July 22nd, 2018.
Definition / general
  • Classified as pyloric, intestinal, foveolar and biliary
  • Intestinal subtypes includes tubular, papillary and tubulopapillary (Hum Pathol 2012;43:1506)
  • By definition, contains at least low grade dysplastic epithelium
  • Found in 0.5% of cholecystectomy specimens, usually asymptomatic
  • Increased prevalence found with familial adenomatous polyposis or Peutz-Jeghers syndrome
  • 70% women
  • Carcinoma within adenoma found in 23% in one study (Korean J Gastroenterol 2010;55:119) but invasive carcinoma rare if < 1 cm
  • Entire lesion should be submitted for microscopic examination
  • Not a premalignant lesion since different molecular abnormalities from carcinoma (Hum Pathol 1999;30:21)
  • Mutations in RAS / RAF / MAPK pathways in adenomas, not adenocarcinomas (Appl Immunohistochem Mol Morphol 2011;19:133)
  • Pyloric gland adenoma can progress to carcinoma and be associated with invasion and fatal outcome (Am J Surg Pathol 2012;36:1279)
Treatment
  • Total excision
Gross description
  • 3 - 25 mm polypoid structure projecting into lumen
  • May be sessile
  • 90% are single
Gross images

Images hosted on other servers:

Tubular adenoma

Microscopic (histologic) description
  • Biliary adenoma: composed of columnar cells similar to normal biliary cells of gallbladder
  • Foveolar adenoma: has low grade dysplasia
  • Pyloric gland adenoma: usually tubular with pyloric gland features; squamoid morules in 28%
  • High grade dysplasia common in pyloric and intestinal adenomas
Microscopic (histologic) images

Images hosted on other servers:

Tubular adenoma

Positive stains