Gallbladder - Carcinoid tumor

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Gallbladder

Malignant gallbladder tumors

Carcinoid tumor

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Carcinoid tumors in general are rare in gallbladder and may be associated with MEN syndromes and Zollinger-Ellison syndrome
● 10 year survival of 36% in one study (Ann Diagn Pathol 2009;13:378)

Case reports
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● 35 year old woman with clinical cholelithiasis (J Indian Med Assoc 2011;109:198)
● 35 year old woman with 20 cm mass (Hepatobiliary Pancreat Dis Int 2009;8:326)
● 38 year old man with von Hippel-Lindau disease and clear cell carcinoid tumor (Am J Surg Pathol 2001;25:1334)
● 46 year old woman with 5 cm mass (World J Surg Oncol 2010;8:12)
● 52 year old woman with 7 mm tumor (BMJ Case Rep. 2009;2009 Epub 2009 May 25)
● 57 year old Caucasian man who underwent laparoscopic cholecystectomy (J Med Case Rep 2011;5:334)
● 64 year old man without von Hippel-Lindau disease (Arch Pathol Lab Med 2003;127:745)

Gross images
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Tumor (arrow) in body and fundus

Micro description
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● Nests and tubules of clear cells containing lipid
● May have pagetoid spread into biliary epithelium
● Resembles clear cell endocrine pancreatic neoplasm associated with von Hippel-Lindau disease

Micro images
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Various images

Positive stains
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● AE1-AE3, CK7, chromogranin, synaptophysin
● Inhibin in von Hippel Lindau patients

Negative stains
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● Serotonin

Differential diagnosis
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● Metastatic renal cell carcinoma

End of Gallbladder > Malignant gallbladder tumors > Carcinoid tumor

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