Table of ContentsDefinition / general
Cite this page: Gulwani, H. Dysplasia - carcinoma sequence. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderdyplasiacarcinoma.html. Accessed July 22nd, 2018.
Definition / general
- Suggested route for development of invasive carcinoma of gallbladder (Arch Pathol Lab Med 2005;129:386)
Gallstones → chronic inflammation → antral type metaplasia → intestinal metaplasia → dysplasia → carcinoma
- Major pathway to invasive gallbladder carcinoma is via dysplasia; adenomas do not appear to be important precursors
- Hyperplasia may not be part of this sequence