Gallbladder - Dysplasia-carcinoma sequence

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Gallbladder

Dysplasia

Dysplasia-carcinoma sequence

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 10 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Suggested route for development of invasive carcinoma of gallbladder (Arch Pathol Lab Med 2005;129:386)

Gallstones → chronic inflammation → antral-type metaplasia → intestinal metaplasia → dysplasia → carcinoma

● Major pathway to invasive gallbladder carcinoma is via dysplasia; adenomas do not appear to be important precursors
● Hyperplasia may not be part of this sequence

End of Gallbladder > Dysplasia > Dysplasia-carcinoma sequence

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