Dysplasia - carcinoma sequence

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 6 February 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Dysplasia carcinoma sequence gallbladder

Table of Contents
Definition / general
Cite this page: Gulwani, H. Dysplasia - carcinoma sequence. website. Accessed July 22nd, 2018.
Definition / general
  • Suggested route for development of invasive carcinoma of gallbladder (Arch Pathol Lab Med 2005;129:386)

    Gallstones → chronic inflammation → antral type metaplasia → intestinal metaplasia → dysplasia → carcinoma

  • Major pathway to invasive gallbladder carcinoma is via dysplasia; adenomas do not appear to be important precursors
  • Hyperplasia may not be part of this sequence