Extrahepatic bile ducts - Dysplasia of extrahepatic bile ducts

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Extrahepatic bile ducts

Tumors

Dysplasia of extrahepatic bile ducts

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Spectrum from hyperplasia to high grade dysplasia to invasive adenocarcinoma exists, similar to intraductal papillary mucinous neoplasms
● High grade dysplasia at cystic duct margin is rare without invasive carcinoma (HPB (Oxford) 2011;13:865)
● Almost universally abnormally short telomeres (Mod Pathol 2006;19:772)

Micro description
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● May have prominent subnuclear vacuoles

Cytology images
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High grade dysplasia of cystic duct margin

Figures 3 and 4

Positive stains
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● Cell adhesion molecules (P-cadherin and CD24, Hum Pathol 2010;41:1558)

Negative stains
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● Usually CD10- in high grade dysplasia (Am J Surg Pathol 2012;36:101)

Differential diagnosis
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● Papillary hyperplasia

End of Extrahepatic bile ducts > Tumors > Dysplasia of extrahepatic bile ducts

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