Extrahepatic bile ducts
Dysplasia of extrahepatic bile ducts
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Spectrum from hyperplasia to high grade dysplasia to invasive adenocarcinoma exists, similar to intraductal papillary mucinous neoplasms
● High grade dysplasia at cystic duct margin is rare without invasive carcinoma (HPB (Oxford) 2011;13:865)
● Almost universally abnormally short telomeres (Mod Pathol 2006;19:772)
● May have prominent subnuclear vacuoles
High grade dysplasia of cystic duct margin
Figures 3 and 4
● Cell adhesion molecules (P-cadherin and CD24,
Hum Pathol 2010;41:1558)
● Usually CD10- in high grade dysplasia (Am J Surg Pathol 2012;36:101)
● Papillary hyperplasia
End of Extrahepatic bile ducts > Tumors > Dysplasia of extrahepatic bile ducts
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