Eosinophilic cholecystitis

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 2 February 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Eosinophilic cholecystitis gallbladder

Cite this page: Gulwani, H. Eosinophilic cholecystitis. website. Accessed July 21st, 2018.
Definition / general
  • Restrict usage to inflammatory infiltrates composed almost entirely of eosinophils, since eosinophils are common in subacute cholecystitis
  • 1 - 5% of resected gallbladders
  • Often involves muscular layer but may be transmural or mucosal
  • Associated with gallstones, fibroblasts
  • Churg-Strauss syndrome: granulomatous angiitis with eosinophilia
  • Idiosyncratic reaction to biliary contents
  • Less commonly due to ampicillin, atopy, cephalosporin, eosinophilic cholangitis, eosinophilic enterocolitis or appendicitis, erythromycin, hypereosinophilic syndrome, interleukin 2 and lymphokine activated killer cells, lymphoplasmacytic sclerosing pancreatitis, parasitic infection, peripheral eosinophilia (Am J Surg Pathol 2003;27:334)
Case reports
Clinical images

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Thick gallbladder
with no evidence
of cyst or
lymph node

Gross images

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Very thick gallbladder wall

Microscopic (histologic) images

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Eosinophils infiltrating all layers of gallbladder wall

Eosinophils form
component of
inflammatory infiltrate