Extrahepatic bile ducts
Granular cell tumor of extrahepatic bile ducts
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Most common benign nonepithelial tumor of extrahepatic biliary tree
● Usually young to middle-aged (mean 34 years) black (65%) women (91%)
Biliary tree sites:
● Common bile duct or cystic duct
● Also gallbladder (4%), intrahepatic ducts (4%)
● 31 year old woman with painless jaundice and pruritus
(Acta Chir Iugosl 2008;55:99)
● Nonencapsulated, 85% solitary, < 3 cm, yellow-tan-white
Common hepatic duct tumor
Distal common bile duct tumor
● Large polygonal cells with abundant, eosinophilic, granular cytoplasm and central, small, dark, uniform nuclei
Large polygonal cells with eosinophilic and granular cytoplasm
● S100, PAS+ granules, inhibin-alpha (Am J Surg Pathol 2001;25:1200)
End of Extrahepatic bile ducts > Tumors > Granular cell tumor of extrahepatic bile ducts
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