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Extrahepatic bile ducts

Tumors

Granular cell tumor of extrahepatic bile ducts


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Most common benign nonepithelial tumor of extrahepatic biliary tree
● Usually young to middle-aged (mean 34 years) black (65%) women (91%)

Biliary tree sites:
● Common bile duct or cystic duct
● Also gallbladder (4%), intrahepatic ducts (4%)

Case reports
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● 31 year old woman with painless jaundice and pruritus (Acta Chir Iugosl 2008;55:99)

Gross description
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● Nonencapsulated, 85% solitary, < 3 cm, yellow-tan-white

Gross images
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Common hepatic duct tumor


Distal common bile duct tumor

Micro description
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● Large polygonal cells with abundant, eosinophilic, granular cytoplasm and central, small, dark, uniform nuclei

Micro images
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Large polygonal cells with eosinophilic and granular cytoplasm

Positive stains
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● S100, PAS+ granules, inhibin-alpha (Am J Surg Pathol 2001;25:1200)

End of Extrahepatic bile ducts > Tumors > Granular cell tumor of extrahepatic bile ducts


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