Malignant gallbladder tumors
Large cell neuroendocrine carcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 6 February 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Large cell neuroendocrine carcinoma gallbladder

Cite this page: Gulwani, H. Large cell neuroendocrine carcinoma. website. Accessed November 17th, 2018.
Definition / general
  • Very rare (< 10 cases reported)
  • Similar to pulmonary counterpart
Case reports
Microscopic (histologic) description
  • Organoid growth pattern with rosettes and necrosis
  • Large cells, prominent nucleoli, coarse chromatin, high mitotic rate
  • May have intestinal metaplasia of tumor cells or adjacent mucosa
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
  • Endocrine markers