Gallbladder - Large cell neuroendocrine carcinoma

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Gallbladder

Malignant gallbladder tumors

Large cell neuroendocrine carcinoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Very rare (<10 cases reported)
● Similar to pulmonary counterpart

Case reports
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● Report of two cases (Am J Surg Pathol 2000;24:1424)

Micro description
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● Organoid growth pattern with rosettes and necrosis
● Large cells, prominent nucleoli, coarse chromatin, high mitotic rate
● May have intestinal metaplasia of tumor cells or adjacent mucosa

Micro images
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Various images

Positive stains
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● Endocrine markers

Negative stains
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● High molecular weight cytokeratin

End of Gallbladder > Malignant gallbladder tumors > Large cell neuroendocrine carcinoma

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