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Gallbladder

Miscellaneous non-tumor

Metaplasia

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Usually gastric or intestinal, rarely squamous
● Associated with older age, gallstones

Bone metaplasia

Case reports
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● 29 year old woman with osseous metaplasia (Case of the Week #234)
● 53 year old woman with abdominal pain (South Med J 2009;102:322)
● Bone metaplasia in the gallbladder wall (Eksp Klin Gastroenterol 2011;(8):86)

Cartilaginous metaplasia

Case reports
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● Infant with extrahepatic biliary atresia with cartilaginous metaplasia (J Clin Pathol 2008;61:965)

Gastric gland metaplasia

General
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● 66-84% of cholecystectomy specimens
● Pyloric, antral or mucous glands
● Glands usually scattered in lamina propria but may extend into muscular layer
● May form polyps
● Don’t call adenoma unless dysplasia present

Micro images
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Various images

Positive stains
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● Acid mucin positive (Acta Gastroenterol Latinoam 2007;37:11)

Intestinal metaplasia

General
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● Very common finding in cholecystectomy specimens (up to 86%, Sao Paulo Med J 2008;126:220)
● Goblet cells, endocrine cells, Paneth cells, absorptive cells
● Also pyloric gland metaplasia
● Rarely forms polyps
● Case reports: 78 year old man and 62 year old woman (Gut 2001;48:719)

Micro images
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Various images

Additional references
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● Hum Pathol 2009;40:1762, Hum Pathol 2007;38:66, Am J Surg Pathol 2004;28:1253, J Clin Pathol 2006;59:328)

Squamous metaplasia

Case reports
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● 47 year old woman with gastric heterotopia and squamous metaplasia (Acta Gastroenterol Latinoam 2007;37:164)
● 56 year old woman with pseudoepidermoid cyst arising from exuberant squamous metaplasia (Arch Pathol Lab Med 2005;129:e138)

Micro images
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Various images

End of Gallbladder > Miscellaneous non-tumor > Metaplasia

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