Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Gallbladder

Miscellaneous non-tumor

Metaplasia


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Usually gastric or intestinal, rarely squamous
● Associated with older age, gallstones


Bone metaplasia

Case reports
=========================================================================

● 29 year old woman with osseous metaplasia (Case of the Week #234)
● 53 year old woman with abdominal pain (South Med J 2009;102:322)
● Bone metaplasia in the gallbladder wall (Eksp Klin Gastroenterol 2011;(8):86)


Cartilaginous metaplasia

Case reports
=========================================================================

● Infant with extrahepatic biliary atresia with cartilaginous metaplasia (J Clin Pathol 2008;61:965)


Gastric gland metaplasia

General
=========================================================================

● 66-84% of cholecystectomy specimens
● Pyloric, antral or mucous glands
● Glands usually scattered in lamina propria but may extend into muscular layer
● May form polyps
● Donít call adenoma unless dysplasia present

Micro images
=========================================================================



Various images

Positive stains
=========================================================================

● Acid mucin positive (Acta Gastroenterol Latinoam 2007;37:11)


Intestinal metaplasia

General
=========================================================================

● Very common finding in cholecystectomy specimens (up to 86%, Sao Paulo Med J 2008;126:220)
● Goblet cells, endocrine cells, Paneth cells, absorptive cells
● Also pyloric gland metaplasia
● Rarely forms polyps
● Case reports: 78 year old man and 62 year old woman (Gut 2001;48:719)

Micro images
=========================================================================



Various images

Additional references
=========================================================================

Hum Pathol 2009;40:1762, Hum Pathol 2007;38:66, Am J Surg Pathol 2004;28:1253, J Clin Pathol 2006;59:328)


Squamous metaplasia

Case reports
=========================================================================

● 47 year old woman with gastric heterotopia and squamous metaplasia (Acta Gastroenterol Latinoam 2007;37:164)
● 56 year old woman with pseudoepidermoid cyst arising from exuberant squamous metaplasia (Arch Pathol Lab Med 2005;129:e138)

Micro images
=========================================================================



Various images

End of Gallbladder > Miscellaneous non-tumor > Metaplasia


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).