Extrahepatic bile ducts
Normal histology

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 7 February 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Normal histology extrahepatic bile ducts[TIAB]

Cite this page: Gulwani, H. Normal histology. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladdernormalhistologybileduct.html. Accessed June 20th, 2018.
  • May want to submit entire specimen
  • Submit margins separately, including hepatic margin (if liver tissue present)
Surface epithelium:
  • Composed of tall, uniform, columnar cells
  • Mucosa forms irregular pleats or small longitudinal folds

Peribiliary mucous glands:
  • Considered a local progenitor cell niche in extrahepatic biliary epithelium (Liver Int 2012;32:554)
  • Unevenly distributed within large intrahepatic ducts and all extrahepatic bile ducts
  • Lobular architecture; are surrounded by fibroconnective tissue (important in differentiating from well differentiated carcinoma)

Subepithelial region:
  • Dense, hypocellular connective tissue, few lymphocytes
  • Overlies loose connective tissue with elastic fibers and smooth muscle fibers that are most prominent distally but absent or sparse proximally

Muscle layer:
  • Not well defined until distal common bile duct / lower 1/3 of extrahepatic bile duct (Am J Surg Pathol 2000;24:660)
  • Upper 1/3 has no muscle layer or scattered muscle fibers
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
  • Peribiliary glands: amylase, trypsin, lipase