Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 10 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Bile excretion is normally 500-1000 ml/day
● Bile is concentrated 5-10x via active absorption of electrolytes accompanied by passive movement of water
● Cholecystokinin causes gallbladder contraction and release of stored bile into gut
● Bile is critical for intestinal absorption of dietary fat, but the gallbladder is not
● Bile is 2/3 bile salts, bicarbonate rich, has 3% organic solutes
● 95% of secreted bile salts is reabsorbed in ileum and returned to liver via portal blood, called enterohepatic circulation of bile salts
● Cholesterol is eliminated by loss of 0.5 g of bile salts per day
● Cholates, chenodeoxycholates, deoxycholates, lithocholates, ursodeoxycholates
● Major hepatic products of cholesterol metabolism
● A family of water-soluble sterols with carboxylated side chains
● Are highly effective detergents, solubilize water-insoluble lipids secreted by the liver (usually lecithin) into the biliary tree and promote dietary lipid absorption within the gut
● Hydrophobic, non-aqueous
● Has minimal solubility in water
End of Gallbladder > Normal physiology
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).