Gallbladder
Cholecystitis
Porcelain gallbladder

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 2 February 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Porcelain gallbladder[TI]

Cite this page: Gulwani, H. Porcelain gallbladder. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderporcelaingb.html. Accessed April 20th, 2018.
Definition / general
  • Dense, paucicellular hyaline fibrosis transforming gallbladder wall into relatively thin and uniform band
  • Diffusely effaces most of normal structure, some cases show calcifications
  • Also called hyalinizing cholecystitis
  • 0.5% of cholecystectomies - 20% of cases associated with gallbladder carcinoma
Gross description
  • Pearly white appearance due to dystrophic calcification
Gross images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Widely scattered and bland appearing glands embedded in thin band of hyaline stroma, commonly showing a disappearing lining, leaving behind granular, necrotic intraluminal debris (regression) with or without calcification (Am J Surg Pathol 2011;35:1104)
  • Surface epithelium, if preserved, typically shows carcinoma in situ of either denuding or micropapillary types
  • Glandular elements in wall should raise suspicion of carcinoma, since benign glands are usually sparse
Differential diagnosis
  • Carcinoma of gallbladder: glands have longitudinal axis parallel to the surface, irregular contours, clear cytoplasm with distinct borders, nuclear irregularities, washed out chromatin