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Malignant gallbladder tumors


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Primary gallbladder sarcoma is rare (Am J Surg Pathol 2009;33:826)
● MFH is most common, then leiomyosarcoma, rarely angiosarcoma
● Older female adults who usually present with acute cholecystitis, abdominal pain, weight loss, pruritus, leukocytosis, elevated alkaline phosphatase and bilirubin
● Overall poor prognosis (Dig Dis Sci 2009;54:395), except botryoid embryonal RMS (young children), which may have excellent prognosis

Differential diagnosis

Sarcomatoid / spindle cell carcinoma: keratin+ / CK18+

End of Gallbladder > Malignant gallbladder tumors > Sarcoma

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