Gallbladder - Sarcomatoid carcinoma

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Gallbladder

Malignant gallbladder tumors

Sarcomatoid carcinoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 15 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Also called spindle cell carcinoma, carcinosarcoma
● < 50 cases reported in gallbladder
● Usually elderly women
● Both components (spindled and epithelial) appear to be derived from single clone (Hum Pathol 2004;35:418)
● Usually death within 6 months of diagnosis

Case reports
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● 59 year old woman (BMJ Case Rep 2011 Apr 1;2011)
● 61 year old woman with tumor containing rhabdoid component (Arch Pathol Lab Med 2003;127:e406)

Gross description
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● Polypoid, firm, solid, yellow-gray, granular with necrosis

Gross images
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Courtesy of Dr. Semir Vranic, University of Sarajevo, Bosnia and Herzegovina

Micro description
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● Malignant epithelial and sarcomatous components
● Neoplastic glands contain mucin or rarely include squamous cell carcinoma
● Sarcomatous component consists of pleomorphic or spindle cells, sometimes with heterologous osteosarcoma, chondrosarcoma or rhabdomyosarcoma

Micro images
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Tumor with rhabdoid component, CK+, vimentin+

Courtesy of Dr. Semir Vranic, University of Sarajevo, Bosnia and Herzegovina

Positive stains
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● Cytokeratin and EMA in both components
● CEA in epithelial component

End of Gallbladder > Malignant gallbladder tumors > Sarcomatoid carcinoma

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