Gallbladder
Malignant gallbladder tumors
Sarcomatoid carcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 7 February 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Sarcomatoid carcinoma[TIAB] gallbladder

Cite this page: Gulwani, H. Sarcomatoid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladdersarcomatoidcarcinoma.html. Accessed February 24th, 2018.
Definition / general
  • Also called spindle cell carcinoma, carcinosarcoma
  • < 50 cases reported in gallbladder
  • Usually elderly women
  • Both components (spindled and epithelial) appear to be derived from single clone (Hum Pathol 2004;35:418)
  • Usually death within 6 months of diagnosis
Case reports
Gross description
  • Polypoid, firm, solid, yellowish gray, granular with necrosis
Gross images

Images hosted on PathOut server:

Images contributed by Dr. Semir Vranić, University of Sarajevo, Bosnia and Herzegovina:

Microscopic (histologic) description
  • Malignant epithelial and sarcomatous components
  • Neoplastic glands contain mucin or rarely include squamous cell carcinoma
  • Sarcomatous component consists of pleomorphic or spindle cells, sometimes with heterologous osteosarcoma, chondrosarcoma or rhabdomyosarcoma
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Dr. Semir Vranić, University of Sarajevo, Bosnia and Herzegovina:






Images hosted on other servers:

Tumor with rhabdoid component, CK+, vimentin+

Positive stains