Extrahepatic bile ducts
Secondary sclerosing cholangitis

Topic Completed: 1 September 2012

Minor changes: 13 September 2019

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PubMed Search: Secondary sclerosing cholangitis extrahepatic bile ducts

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Secondary sclerosing cholangitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladdersecondarysclerosingcholangitis.html. Accessed June 1st, 2020.
Definition / general
  • Much more common than primary sclerosing cholangitis
  • Biliary obstruction (choledochal cyst, choledocholithiasis, chronic pancreatitis, extrahepatic biliary atresia, postoperative), infection (immunodeficiency states), ischemia, malignancy, other (chronic graft vs. host disease, Langerhans cell histiocytosis, sarcoidosis, systemic mastocytosis), toxins
  • Associated with hepatic lobar atrophy, bacterial infection (Postgrad Med J 2007;83:773)
Case reports
Microscopic (histologic) description
  • Fibrosis, inflammation, ulceration, foreign body granulomas
Microscopic (histologic) images

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Eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis

Differential diagnosis
  • Bile duct carcinoma: infiltrating glands, often marked cytologic atypia, perineural invasion; no lobular pattern of peribiliary glands, no concentric fibrosis around peribiliary glands
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