Benign gallbladder tumors
Signet ring cells
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update September 2012
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● Represent hyperplastic and degenerative change of mucosal goblet cells, non-neoplastic (Hum Pathol 2009;40:326)
● Seen on mucosal surface and lumen of tubules
● Signet ring cells that lack nuclear atypia, arranged in superficial and intraluminal nests
● Admixture with histiocytes and other inflammatory cells
Signet-ring cells in gallbladder wall immediately beneath mucosa
Signet-ring cells arranged in nodular collections within glandular lumina surrounded by lamina propria; are AE1-AE3+
● Mayer's mucicarmine; AE1/AE3
● Signet ring cell carcinoma
End of Gallbladder > Benign gallbladder tumors > Signet ring cells
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