Signet ring cells

Topic Completed: 1 September 2012

Revised: 5 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Signet ring cells gallbladder

Hanni Gulwani, M.B.B.S.
Page views in 2018: 265
Page views in 2019 to date: 317
Cite this page: Gulwani H. Signet ring cells. website. Accessed November 21st, 2019.
Definition / general
  • Represent hyperplastic and degenerative change of mucosal goblet cells, nonneoplastic (Hum Pathol 2009;40:326)
  • Seen on mucosal surface and lumen of tubules
Microscopic (histologic) description
  • Signet ring cells that lack nuclear atypia, arranged in superficial and intraluminal nests
  • Admixture with histiocytes and other inflammatory cells
Microscopic (histologic) images

Images hosted on other servers:

Signet ring cells in gallbladder wall immediately beneath mucosa

Signet ring cells arranged in nodular collections within glandular lumina surrounded by lamina propria; are AE1 / AE3+

Positive stains
Differential diagnosis
  • Signet ring cell carcinoma
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