Gallbladder
Miscellaneous nontumor
Signet ring cells


Topic Completed: 1 September 2012

Revised: 15 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Signet ring cells gallbladder

Hanni Gulwani, M.B.B.S.
Page views in 2018: 265
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Cite this page: Gulwani H Signet ring cells. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladdersignetring.html. Accessed July 19th, 2019.
Definition / general
  • Represent hyperplastic and degenerative change of mucosal goblet cells, nonneoplastic (Hum Pathol 2009;40:326)
  • Seen on mucosal surface and lumen of tubules
Microscopic (histologic) description
  • Signet ring cells that lack nuclear atypia, arranged in superficial and intraluminal nests
  • Admixture with histiocytes and other inflammatory cells
Microscopic (histologic) images

Images hosted on other servers:

Signet ring cells in gallbladder wall immediately beneath mucosa

Signet ring cells arranged in nodular collections within glandular lumina surrounded by lamina propria; are AE1 / AE3+

Positive stains
Differential diagnosis
  • Signet ring cell carcinoma
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