Miscellaneous nontumor
Signet ring cells

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 5 February 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Signet ring cells gallbladder

Page views in 2018: 265
Page views in 2019 to date: 16
Cite this page: Gulwani, H. Signet ring cells. website. Accessed January 21st, 2019.
Definition / general
  • Represent hyperplastic and degenerative change of mucosal goblet cells, nonneoplastic (Hum Pathol 2009;40:326)
  • Seen on mucosal surface and lumen of tubules
Microscopic (histologic) description
  • Signet ring cells that lack nuclear atypia, arranged in superficial and intraluminal nests
  • Admixture with histiocytes and other inflammatory cells
Microscopic (histologic) images

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Signet ring cells in gallbladder wall immediately beneath mucosa

Signet ring cells arranged in nodular collections within glandular lumina surrounded by lamina propria; are AE1 / AE3+

Positive stains
Differential diagnosis
  • Signet ring cell carcinoma