Gallbladder
Miscellaneous
TNM staging for carcinoma of gallbladder and cystic duct

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 8 February 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: TNM staging for carcinoma of gallbladder and cystic duct

Cite this page: Gulwani, H. TNM staging for carcinoma of gallbladder and cystic duct. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderstaging.html. Accessed February 24th, 2018.
Definition / general
  • Classification excludes sarcomas and carcinoid tumors
Primary tumor (T) - carcinoma of gallbladder and cystic duct
  • TX: Primary tumor cannot be assessed
  • T0: No evidence of primary tumor
  • Tis: Carcinoma in situ
  • T1: Tumor invades lamina propria or muscular layer
  • T1a: Tumor invades lamina propria
  • T1b: Tumor invades muscular layer
  • T2: Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver
  • T3: Tumor perforates the serosa (visceral peritoneum) or directly invades the liver or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum or extrahepatic bile ducts
  • T4: Tumor invades main portal vein or hepatic artery or invades two or more extrahepatic organs or structures
Regional lymph nodes (N) - carcinoma of gallbladder and cystic duct
  • NX: Regional lymph nodes cannot be assessed
  • N0: No regional lymph node metastasis
  • N1: Metastasis to nodes along the cystic duct, common bile duct, hepatic artery or portal vein
  • N2: Metastases to periaortic, pericaval, superior mesenteric artery or celiac artery lymph nodes
Distant metastasis (M) - carcinoma of gallbladder and cystic duct
  • M0: No distant metastasis
  • M1: Distant metastasis
Stage grouping - carcinoma of gallbladder and cystic duct
  • 0: Tis N0 M0
  • I: T1 N0 M0
  • II: T2 N0 M0
  • IIIA: T3 N0 M0
  • IIIB: T1 - 3 N1 M0
  • IVA: T4 N0 - 1 M0
  • IVB: any T N2 M0 or any T any N M1
Diagrams / tables

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Stage grouping

Pathologic staging (pTNM)
TNM descriptors (required only if applicable, select all that apply)
___ m (multiple primary tumors)
___ r (recurrent)
___ y (posttreatment)