Gallbladder
Cholecystitis
Xanthogranulomatous cholecystitis


Topic Completed: 1 September 2012

Minor changes: 5 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Xanthogranulomatous cholecystitis gallbladder[TI]

Hanni Gulwani, M.B.B.S.
Page views in 2019: 8,692
Page views in 2020 to date: 3,567
Cite this page: Gulwani H. Xanthogranulomatous cholecystitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/gallbladderxanthogranulomatous.html. Accessed June 4th, 2020.
Definition / general
  • 1 - 2% of surgically excised gallbladders
  • Usually women ages 60 - 70 years
  • Due to rupture of Rokitansky-Aschoff sinuses with extravasation of bile or ulceration of gallbladder mucosa
  • Resembles carcinoma at surgery; often associated with extended surgical resections (Dig Surg 2012;29:187, Gut Liver 2010;4:518)
  • Frozen sections may prevent extended resections (Cell Biochem Biophys 2012;64:131)
  • Complications include perforation, abscess formation, fistulous tracts, extension to liver, colon or soft tissue
  • Associated with malignancy
Case reports
Gross description
  • Yellow brown, poor to well demarcated foci of wall thickening with variable ulceration, simulates neoplasm
Gross images

Images hosted on other servers:

Diffuse wall thickening

Microscopic (histologic) description
  • Foamy macrophages or macrophages with ceroid, bile or iron
  • Also cholesterol clefts and multinucleated giant cells
  • May be focal, nodular or diffuse
  • May contain lymphocytes, plasma cells, foreign body giant cells and neutrophils
Microscopic (histologic) images

Images hosted on other servers:

Foamy macrophages and chronic inflammatory cells

Back to top