Cardiac tumors - malignant
Germ cell tumor / teratoma

Topic Completed: 1 November 2013

Revised: 27 September 2019

Copyright: 2007-2019, PathologyOutlines.com, Inc.

PubMed Search: Germ cell tumor [title] heart

Nat Pernick, M.D.
Page views in 2018: 174
Page views in 2019 to date: 199
Cite this page: Pernick N. Germ cell tumor / teratoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorgermcell.html. Accessed December 8th, 2019.
Definition / general
  • Rare
  • Most cardiac germ cell tumors are teratomas
  • Most common site is interventricular septum, extending into right ventricle
  • Benign if pure teratoma but malignant if other germ cell elements are present (choriocarcinoma, embryonal carcinoma, yolk sac tumor) or if squamous cell carcinoma arises from teratoma
Case reports
  • Excision
Gross description
  • Teratomas are multicystic with solid areas, up to 15 cm
Gross images
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Newborn who died at birth has bulging mass in right ventricular outflow tract (arrows), PV - pulmonary valve

Microscopic (histologic) description
  • Teratoma: squamous or mucous lined cysts, smooth muscle, cartilage, neuroglial tissue; also intestinal, pancreatic, ependymal tissue and bone; often myxoid stroma
Microscopic (histologic) images
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Cysts on endocardial surface (trichrome)

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Neural and glandular structures and stroma

Differential diagnosis
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