Cardiac tumors - malignant
Germ cell tumor / teratoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 March 2018, last major update November 2013

Copyright: (c) 2007-2018, PathologyOutlines.com, Inc.

PubMed Search: Germ cell tumor [title] heart

Cite this page: Pernick, N. Germ cell tumor / teratoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorgermcell.html. Accessed October 23rd, 2018.
Definition / general
  • Rare
  • Most cardiac germ cell tumors are teratomas
  • Most common site is interventricular septum, extending into right ventricle
  • Benign if pure teratoma but malignant if other germ cell elements are present (choriocarcinoma, embryonal carcinoma, yolk sac tumor) or if squamous cell carcinoma arises from teratoma
Case reports
  • Excision
Gross description
  • Teratomas are multicystic with solid areas, up to 15 cm

Images hosted on PathOut server:
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Newborn who died at birth has bulging mass in right ventricular outflow tract (arrows), PV - pulmonary valve

Microscopic (histologic) description
  • Teratoma: squamous or mucous lined cysts, smooth muscle, cartilage, neuroglial tissue; also intestinal, pancreatic, ependymal tissue and bone; often myxoid stroma
Microscopic (histologic) images

Images hosted on PathOut server:

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Cysts on endocardial surface (trichrome)

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Neural and glandular structures and stroma

Differential diagnosis