Heart
Cardiac tumors - benign
Hamartoma of mature cardiac myocytes



Topic Completed: 1 November 2013

Revised: 26 February 2019

Copyright: 2007-2019, PathologyOutlines.com, Inc.

PubMed Search: Hamartoma of mature cardiac myocytes


Nat Pernick, M.D.
Page views in 2018: 195
Page views in 2019 to date: 76
Cite this page: Pernick N Hamartoma of mature cardiac myocytes. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorhamartoma.html. Accessed June 19th, 2019.
Definition / general
  • Rare
Case reports
Gross description
  • Resembles hypertrophic cardiomyopathy but has localized masses or multiple discrete masses, usually in right ventricle or atrium
  • No septal asymmetry (Hum Pathol 1998;29:904)
Gross images
Missing Image

Right ventricular mass

Microscopic (histologic) description
  • Discrete but unencapsulated nodules of marked myocyte hypertrophy with disorganization (resembles hypertrophic cardiomyopathy), focal scarring and thickened intramural arteries
  • No myocyte vacuoles
Microscopic (histologic) images
Missing Image

Disorganized cardiac cells with prominent nuclei

Missing Image

Haphazard hypertrophied myocytes and fibrosis

Electron microscopy description
  • Abundant and disorganized myofilaments
  • Normal intercellular junctions
Differential diagnosis
  • Oncocytic cardiomyopathy
  • Rhabdomyoma: myocyte vacuoles
Back to top