Malignant tumors

Topic Completed: 1 May 2007

Minor changes: 27 September 2019

Copyright: 2007-2019, PathologyOutlines.com, Inc.

PubMed Search: Hemangioendothelioma heart

Nat Pernick, M.D.
Page views in 2019: 2,537
Page views in 2020 to date: 1,600
Cite this page: Pernick N. Hemangioendothelioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorhemangioendothelioma.html. Accessed July 7th, 2020.
Definition / general
  • See also Soft Tissue chapter
  • Rare in heart
  • Vascular tumor of intermediate malignancy
  • 10% of extracardiac tumors metastasize and 1/3 recur
Case reports
Microscopic (histologic) description
  • Polygonal cells with abundant cytoplasm and intracytoplasmic vacuoles
  • Epithelioid tumors have short strands or solid nests of round/oval endothelial cells with small intracellular lumina
  • Infiltrate muscular walls of vessels
Microscopic (histologic) images
Case of the Week #401

Low power view


CD31 (20x)




Other images

71 year old woman with left atrial mass has tumor cells with abundant cytoplasm and large, intracytoplasmic vacuoles; tumor cells are CD34+

Positive stains
  • Factor VIII related antigen, CD34
Differential diagnosis
  • Adenocarcinoma
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