Heart tumor
Malignant
Hemangioendothelioma

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 20 September 2016, last major update May 2007

Copyright: (c) 2007-2016, PathologyOutlines.com, Inc.

PubMed Search: Hemangioendothelioma heart
Definition / General
  • See also Soft Tissue chapter
  • Rare in heart
  • Vascular tumor of intermediate malignancy
  • 10% of extracardiac tumors metastasize and 1/3 recur
Case Reports
Micro Description
  • Polygonal cells with abundant cytoplasm and intracytoplasmic vacuoles
  • Epithelioid tumors have short strands or solid nests of round/oval endothelial cells with small intracellular lumina
  • Infiltrate muscular walls of vessels
Micro Images

Images hosted on PathOut server:

Case of the Week #401:

Low power view

20x


CD31 (20x)

CD34

SMA

Vimentin



Other images:

71 year old woman with left atrial mass has tumor cells with abundant cytoplasm and large, intracytoplasmic vacuoles; tumor cells are CD34+

Positive Stains
  • Factor VIII related antigen, CD34
Differential Diagnosis
  • Adenocarcinoma