Heart tumor

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 19 March 2018, last major update May 2007

Copyright: (c) 2007-2018, PathologyOutlines.com, Inc.

PubMed Search: Hemangioendothelioma heart
Cite this page: Pernick, N. Hemangioendothelioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorhemangioendothelioma.html. Accessed September 22nd, 2018.
Definition / general
  • See also Soft Tissue chapter
  • Rare in heart
  • Vascular tumor of intermediate malignancy
  • 10% of extracardiac tumors metastasize and 1/3 recur
Case reports
Microscopic (histologic) description
  • Polygonal cells with abundant cytoplasm and intracytoplasmic vacuoles
  • Epithelioid tumors have short strands or solid nests of round/oval endothelial cells with small intracellular lumina
  • Infiltrate muscular walls of vessels
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #401:

Low power view


CD31 (20x)




Other images:

71 year old woman with left atrial mass has tumor cells with abundant cytoplasm and large, intracytoplasmic vacuoles; tumor cells are CD34+

Positive stains
  • Factor VIII related antigen, CD34
Differential diagnosis
  • Adenocarcinoma