Heart
Cardiac tumors - malignant
Liposarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 March 2018, last major update October 2014

Copyright: (c) 2007-2018, PathologyOutlines.com, Inc.

PubMed Search: Liposarcoma [title] heart

Cite this page: Pernick, N. Liposarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorliposarcoma.html. Accessed August 16th, 2018.
Definition / general
  • Very rare
  • Mean age 53 years
  • Usually right atrium
  • Metastasizes to lung, liver, bones, CNS
  • Mean survival is 8 months
Case reports
Gross description
  • Bulky tumors up to 10 cm, often cystic, soft, bosselated
  • May have multiple tumor implants on surface of great vessels or diffuse pericardial growth
Gross images

Images hosted on PathOut server:
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Tumor nodules over
posterior epicardium of
left and right ventricles
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Large right atrial tumor overlying tricuspid valve

Microscopic (histologic) description
  • Pleomorphic liposarcoma resembles MFH or fibrosarcoma but with lipoblasts containing multiple vacuoles that indent the cell nuclei
  • Myxoid liposarcoma has prominent plexiform vascular pattern and signet ring type lipoblasts
Microscopic (histologic) images

Images hosted on PathOut server:
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Pleomorphic liposarcoma
with vacuolated cells
in 64 year old man
with atrial mass
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Numerous lipoblasts
with large cytoplasmic
vacuoles that indent
the nucleus
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Numerous lipoblasts with vacuolated cytoplasm

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Signet ring lipoblast in myxoid background

Positive stains
Negative stains
Electron microscopy description
  • Numerous nonmembrane bound lipid droplets fill cytoplasm and are associated with mitochondria
  • Large indented nucleus is at cell periphery
Differential diagnosis