Malignant tumors

Topic Completed: 1 May 2007

Minor changes: 27 September 2019

Copyright: 2007-2019, PathologyOutlines.com, Inc.

PubMed Search: Leiomyosarcoma heart

Nat Pernick, M.D.
Page views in 2019: 299
Page views in 2020 to date: 198
Cite this page: Pernick N. Leiomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorlms.html. Accessed July 7th, 2020.
Definition / general
Radiology images

Contributed by Dr. Shaesta Naseem Zaidi

CT - pulmonary angiogram

Case reports
Clinical images

Images hosted on other servers:

Tumor over ventricle

Gross description
  • 75% in left atrium, may appear to arise from pulmonary vein, sessile lesions may be grossly myxoid (Can J Cardiol 2001;17:331)
  • 30% are multiple
Gross images

Myxoid tumor

Microscopic (histologic) description
  • Compact bundles or fascicles oriented at right angles to each other
  • Spindled or epithelioid smooth muscle cells with cytoplasmic glycogen, blunted nuclei with moderate/marked pleomorphism, necrosis, mitotic activity
  • Occasionally giant cells, perinuclear vacuoles
  • May be low grade with few mitotic figures
Microscopic (histologic) images

Scroll to see all images.

Contributed by Dr. Shaesta Naseem Zaidi, King Khalid University Hospital (Saudi Arabia) - with heterologous differentiation

H&E images




Other images

Low power shows border with normal cardiac muscle

Fascicles intersect at sharp angles and are composed of cells with blunt ended nuclei;
#3-also slight vacuolar appearance

Epithelioid appearance with round/oval nuclei

High power shows hyperchromatic ovoid nuclei with blunt ends

PAS shows diffuse punctate droplets of glycogen

Smooth muscle actin


Images hosted on other servers

Epithelioid and spindled areas

Various images

Positive stains
  • PAS for intracytoplasmic glycogen, trichrome shows longitudinal fibers
  • Actin, desmin (usually)
Negative stains
  • Cytokeratin (may be positive in epithelioid areas), S100
Electron microscopy description
  • Notched or infolded nuclei, thin actin filaments with focal densities, micropinocytotic vesicles, thin but distinct external lamina, dispersed glycogen, rare mitochondria or endoplasmic reticulum
Electron microscopy images

Images hosted on other servers

Various images

Differential diagnosis
Back to top