Cardiac tumors - malignant

Topic Completed: 1 November 2013

Revised: 27 September 2019

Copyright: 2007-2019, PathologyOutlines.com, Inc.

PubMed Search: Osteosarcoma [title] heart

Nat Pernick, M.D.
Page views in 2018: 155
Page views in 2019 to date: 95
Cite this page: Pernick N. Osteosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/hearttumorosteosarcoma.html. Accessed October 16th, 2019.
Definition / general
  • Mean age 38 years
  • 3 - 9% of cardiac sarcomas
  • Clinically resembles myxoma
  • Aggressive, usually causes death or metastases (Am J Surg Pathol 1991;15:289); metastasizes to lymph nodes, thoracotomy incision, lung, thyroid, skin
Case reports
Gross description
  • Usually attached to wall of left atrium as a 4 - 10 cm sessile mass
  • May extend into pulmonary vein
  • Gritty and calcified areas
Microscopic (histologic) description
  • Malignant bone forming cells within a spindled or pleomorphic sarcoma
  • May also have chondroid differentiation or myxoid areas
  • Bone forming areas may be minor with most of tumor resembling MFH or fibrosarcoma
Microscopic (histologic) images
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Atypical cells within osteoid matrix

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Spindled area in left atrial tumor of 16 year old boy

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Lung metastasis resembles fibrosarcoma

Images hosted on other servers:
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Right ventricular outflow tract tumor

Positive stains
Negative stains
Differential diagnosis
  • Myxoma: no osteoid or chondroid malignant cells, has rings or cords of cells, no atypia
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