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Joints
Joint tumors
Fibrous histiocytoma of tendon sheath

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 4 July 2013, last major update June 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See malignant variant below

General
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Case reports
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Treatment
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Gross / clinical images
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Foot

Palmar aspect of middle phalanx of index finger

Firm, nodular, nontender thumb mass

Excised giant cell tumor

Dome-shaped nodule

Well-demarcated yellowish lobulated tumor

Gross description
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Micro description
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Micro images
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2A: H&E with multinucleated giant cells and mononuclear cells; B: mononuclear cells are HAM56+; C: giant cells and some mononuclear cells are TRAP+; 3: differentiation sequence of giant cell tumor

Giant cell

Low power and high power

Circumscribed lobulated nodule

Histiocytes with abundant eosinophilic cytoplasm


Low power view of thumb tumor

High power view of cellular zone

High power view of hypocellular zone

CD68 immunostaining of cellular zone

Ki-67 immunostaining of peripheral zone

CD45 immunostaining of peripheral zone

Electron microscopy description
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Differential diagnosis
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Malignant variant of fibrous histiocytoma of tendon sheath

General
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Micro images
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Radiological, histologic, and FISH/ISH findings in malignant tumors

End of Joints > Joint tumors > Fibrous histiocytoma of tendon sheath


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