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Joints
Joint tumors
Pigmented villonodular synovitis (PVNS)

Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 15 June 2013, last major update June 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Clinical features
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Case reports
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Treatment
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Clinical images
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Knee arthroscopy

Stained synovium

Gross description
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Gross images
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Brownish synovium

Micro description
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Micro images
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Pseudoglandular or cleft-like spaces

Proliferation of polygonal cells

Multinucleated giant cells

Hemosiderin-laden macrophages

Hemosiderin-laden and lipid-laden macrophages

Lipid-laden macrophages


Low power

Medium power

Malignant cases

Hemosiderin deposits, foamy histiocytes and giant cells

Extensive histiocytic proliferation

Virtual slides
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48 year old woman with synovial polyp

54 year old man with tissue from knee joint

Cytology description
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Cytology images
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H&E

Positive stains
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Negative stains
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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FISH: trisomy 5 and 7

Differential diagnosis
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End of Joints > Joint tumors > Pigmented villonodular synovitis (PVNS)


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