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Joints
Non-infective arthritis
Systemic lupus erythematosus
Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 15 June 2013, last major update May 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
General
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- Autoimmune disease that usually presents with mild arthritis or joint effusions
- Destructive joint disease is rare except for those on steroid therapy who rarely can develop aseptic necrosis
- Occasionally there is a progression to rheumatoid-like nonerosive hand deformities (Jaccoud's syndrome, Rheum Dis Clin North Am 1988;14:99, Ann Rheum Dis 1974;33:204)
- Synovial fluid shows less inflammation than rheumatoid arthritis
Clinical images
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Correctable swan-neck deformities and ulnar deviation
Readily correctable swan-neck deformities and subluxation of right fifth MCP
Metacarpal heads-no cartilage damage seen
Non-correctable deformities of PIP joints
Mild ulnar deviation, especially on right
Micro description
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- Changes resemble rheumatoid arthritis, but with more intense surface fibrin deposition and less synovial proliferation and less intense inflammation
- Occasional vasculitis can be seen (Ann Intern Med 1971;74:911)
Micro images
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Synovial membrane
End of Joints > Non-infective arthritis > Systemic lupus erythematosus
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