General
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• Subset of spondyloarthritides and seronegative arthritis
• Lipopolysaccharide antigens stimulate immune system and cause abrupt onset of arthritis in knees and ankles, lasts only 1 year
• Can be associated with inflammatory bowel disease, Crohn disease and ulcerative colitis (J Postgrad Med 2005;51:273, World J Gastroenterol 2009;15:2456)
• Also associated with celiac disease, Whipple disease, collagenous colitis, intestinal bypass surgery

Epidemiology
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• More common in males, with peak incidence at 15-35 years

Etiology
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• Due to bowel infection with Yersinia, Salmonella, Shigella, Campylobacter

Clinical features
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• Usually asymmetric, oligoarticular arthritis involving the lower limbs along with gastrointestinal manifestations of IBD

Prognostic factors
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• IBD related arthritis usually carries worse prognosis

Case reports
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• 58 year old Malay woman with 17 year history of ulcerative colitis with persistent knee effusion (J Med Case Rep 2012;6:10)

Micro images
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Synovial tissue of knee

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