• Thickening (perineural fibrosis) and degeneration of interdigital nerve of foot, usually between third and fourth metatarsal heads (eMedicine)
• Usually women due to poorly fitting shoes
• Sharp shooting pains, worse when standing, that begin in sole of foot and radiate to exterior surface
• Prevalence of 30-33% (Korean J Radiol 2007;8:148)
• Lesions >5mm are more symptomatic than smaller ones

Neuroma removed

• Fusiform swelling proximal to bifurcation of plantar interdigital nerve

• Endarterial thickening of digital artery, often with thrombosis
• Fibrosis around and within nerve
• Schwann cell and fibroblast proliferation
• Also loss of myelinated nerve fibers

• Bursitis, intermetatarsal: see Semin Musculoskelet Radiol 2005;9:175
• Traumatic neuroma: rare, but also in interdigital nerves of feet

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