Nonneoplastic disease
Morton neuroma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 9 July 2018, last major update February 2013

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Morton neuroma

Cite this page: Shankar, V. Morton neuroma. website. Accessed December 17th, 2018.
Definition / general
  • Thickening (perineural fibrosis) and degeneration of interdigital nerve of foot, usually between third and fourth metatarsal heads (eMedicine: Surgery for Morton Neuroma)
  • Usually women due to poorly fitting shoes
  • Sharp shooting pains, worse when standing, that begin in sole of foot and radiate to exterior surface
  • Prevalence of 30 - 33% (Korean J Radiol 2007;8:148)
  • Lesions > 5 mm are more symptomatic than smaller ones
Diagrams / tables

Morton neuroma

Gross description
  • Fusiform swelling proximal to bifurcation of plantar interdigital nerve
Microscopic (histologic) description
  • Endarterial thickening of digital artery, often with thrombosis
  • Fibrosis around and within nerve
  • Schwann cell and fibroblast proliferation
  • Also loss of myelinated nerve fibers
Differential diagnosis