Reviewer: Vijay Shankar, M.D. (see Reviewers page)
Revised: 15 June 2013, last major update May 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Also called progressive systemic sclerosis
- Initially presents with nonspecific joint pains, which can lead to arthritis
- Joint mobility may be restricted by calcinosis or skin thickening
- May be accompanied or even dominated by arthritis and arthralgia
- Serum positive for rheumatoid factor and anticentromere antibodies (Br J Rheumatol 1995;34:831)
- Superficial fibrin deposition in synovial membrane, mild mononuclear infiltrate, mild synovial hyperplasia, proliferation of collagen fibers, focal obliteration of small vessels
End of Joints > Non-infective arthritis > Scleroderma
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