Infections / parasites
Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 1 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Viral infection associated with renal transplants, due to immunosuppression
● May be associated with other viral infections
● Controversial if associated with graft rejection (Nephrol Dial Transplant 2012;27:435)
● In UK, CMV mismatch does not appear to affect patient and graft survival in renal transplant recipients (Transplantation 2009;88:77)
● Symptomatic primary CMV infections are commonly detected after cessation of valganciclovir prophylaxis (Am J Transplant 2010;10:2026, Nephrol Dial Transplant 2009;24:316)
● Recommended to use quantitative PCR rather than serology to monitor CMV infection in pre- and post-transplantation patients (Egypt J Immunol 2010;17:41)
● Large tubular cells with enlarged basophilic nuclei with inclusions and perinuclear halo
● Also tubular injury
Enlarged renal tubular epithelial cells with enlarged basophilic nuclei with inclusions and tubular injury
Round and discrete intranuclear inclusion surrounded by a white thin halo
Electron microscopy description
● Cytoplasmic virus has bulls-eye appearance
End of Kidney non-tumor > Infections/parasites > CMV
Ref Updated: 6/29/12
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).