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Kidney non-tumor

Infections / parasites

CMV


Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 1 September 2012, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Viral infection associated with renal transplants, due to immunosuppression

General
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● May be associated with other viral infections
● Controversial if associated with graft rejection (Nephrol Dial Transplant 2012;27:435)
● In UK, CMV mismatch does not appear to affect patient and graft survival in renal transplant recipients (Transplantation 2009;88:77)
● Symptomatic primary CMV infections are commonly detected after cessation of valganciclovir prophylaxis (Am J Transplant 2010;10:2026, Nephrol Dial Transplant 2009;24:316)
● Recommended to use quantitative PCR rather than serology to monitor CMV infection in pre- and post-transplantation patients (Egypt J Immunol 2010;17:41)

Micro description
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● Large tubular cells with enlarged basophilic nuclei with inclusions and perinuclear halo
● Also tubular injury

Micro images
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Enlarged renal tubular epithelial cells with enlarged basophilic nuclei with inclusions and tubular injury

               
Round and discrete intranuclear inclusion surrounded by a white thin halo

       
Various images

Electron microscopy description
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● Cytoplasmic virus has bulls-eye appearance

End of Kidney non-tumor > Infections/parasites > CMV

Ref Updated: 6/29/12


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