Kidney nontumor
Tubulointestitial disease
Other tubular and interstitial disease
Acute allergic tubulointerstitial nephritis

Topic Completed: 26 November 2018

Minor changes: 17 February 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Acute allergic tubulointerstitial nephritis

Nikhil Sangle, M.D.
Page views in 2019: 401
Page views in 2020 to date: 407
Cite this page: Sangle N. Acute allergic tubulointerstitial nephritis. website. Accessed October 24th, 2020.
Definition / general
  • Drug reaction to beta lactam antibiotics, non-steroidal anti-inflammatory drugs, diuretics, other drugs; generally after 2 – 3 weeks after exposure
  • May occur in renal allografts (Clin Nephrol 2009;72:331)
  • Fever, hematuria, azotemia and eosinophilia
  • Variable skin rash
  • May be associated with inactive cytochrome P450 polymorphisms (Ren Fail 2009;31:749)
  • Urinalysis: suggestive of infection (eosinophils, hematuria, proteinuria, pyuria), but culture negative
Microscopic (histologic) description
  • Generalized interstitial edema and infiltration by lymphocytes, plasma cells, macrophages and eosinophils
  • Tubular epithelial damage (tubulitis) with luminal white blood cells; variable degree of tubular injury
  • Normal glomeruli and vessels
Microscopic (histologic) images

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